PyPy is a fast, compliant alternative implementation of the Python language. It supports most of the commonly used Python standard library modules. Its feature include Just-in-Time compiler, Less memory usage, support Stackless and lot more. PyPy focuses on speed, efficiency and 100% compatibility with the original CPython interpreter. It was conceived as an implementation of Python written in Python, which enables Python developers to hack the implementation. 

PyPy - fast, compliant alternative implementation of the Python language

IronPython is an open-source implementation of the Python programming language which is tightly integrated with the .NET Framework. IronPython can use the .NET Framework and Python libraries, and other .NET languages can use Python code just as easily. It supports an interactive console with fully dynamic compilation.

IronPython - Python programming language for the .NET Framework 

Python for .NET is a package that gives Python programmers nearly seamless integration with the .NET Common Language Runtime (CLR) and provides a powerful application scripting tool for .NET developers. Using this package you can script .NET applications or build entire applications in Python, using .NET services and components written in any language that targets the CLR (Managed C++, C#, VB, JScript). 
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This package does not implement Python as a first-class CLR language - it does not produce managed code (IL) from Python code. Rather, it is an integration of the C Python engine with the .NET runtime. This approach allows you to use use CLR services and continue to use existing Python code and C-based extensions while maintaining native execution speeds for Python code. 

Python for .NET is a package that gives Python programmers nearly seamless integration with the .NET Common Language Runtime (CLR) and provides a powerful application scripting tool for .NET developers. Using this package you can script .NET applications or build entire applications in Python, using .NET services and components written in any language that targets the CLR (Managed C++, C#, VB, JScript). 

Python for .NET - Python integration with the .NET

Cython is a language that makes writing C extensions for the Python language as easy as Python itself. It is based on the well-known Pyrex, but supports more cutting edge functionality and optimizations. It gives you the combined power of Python and C to let you write Python code that calls back and forth from and to C or C++ code natively at any point.
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The Cython language is a superset of the Python language that additionally supports calling C functions and declaring C types on variables and class attributes. This allows the compiler to generate very efficient C code from Cython code. The C code is generated once and then compiles with all major C/C++ compilers in CPython 2.4 and later, including Python 3.x.

Cython is a language that makes writing C extensions for the Python language as easy as Python itself. It is based on the well-known Pyrex, but supports more cutting edge functionality and optimizations. It gives you the combined power of Python and C to let you write Python code that calls back and forth from and to C or C++ code natively at any point.

Cython - C extensions for the Python language

The mypy programming language is an experimental Python variant that aims to combine the benefits of dynamic (or "duck") typing and static typing. The goal is to have the expressive power and convenience of Python, and also compile-time type checking and efficient compilation to native code, without the need of a heavy-weight VM. Mypy will get rid of the Global Interpreter Lock (GIL) that is used in CPython and allow parallel programs to take advantage of multicore processors.

mypy - New Python Variant

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