Claws Mail is a GTK+ based, lightweight, and fast e-mail client and newsreader. Supports POP3, APOP, IMAP, SMTP, SMTP AUTH, NNTP, LDAP, multiple accounts, spell-checking, addressbook, SSL, GPG, filtering, i18n, & more. It is further extended by plugins. Lots of extra functionality, like an RSS aggregator, calendar, or laptop LED handling, are provided by extra plugins. 

Claws Mail - Email Client and News Reader Based on GTK+

Thunderbird is most popular simple e-mail, newsgroup and news feed client. It is comparable to Microsoft outlook. It supports features such as Firefox's tabbed browsing, Email search, Message archive, Spam filtering, Message grouping, SSL, TLS, POP3 and IMAP support and lot more.

Thunderbird - Email Client

SharpWebMail is an ASP.NET webmail application that is written in C#. It uses a POP3 or IMAP servers as the mailstore and sends mail through a SMTP server. It is very simple to configure (only a few settings in the web.config file). You can compose HTML messages, search your inbox, read complex mime messages, have multiple address books and much more.

SharpWebMail - ASP.NET Webmail Application

Sylpheed is a simple, lightweight but featureful, and easy-to-use e-mail client. It provides intuitive user-interface, Powerful filtering and search, Junk mail control, Security features (GnuPG, SSL/TLSv1). Sylpheed supports not only the major protocols such as POP3, IMAP4rev1 and SMTP, but also NNTP (NetNews). IPv6, which is the next-generation Internet protocol, is also supported by default.

Sylpheed - Lightweight and user-friendly e-mail client

All your E-mail, from all your accounts, in one place. Cypht is not your father's webmail. Unless you are one of my daughters, in which case it is your father's webmail. Cypht is like a news reader, but for E-mail. Cypht does not replace your existing accounts - it combines them into one. And it's also a news reader..

Cypht - Lightweight Open Source webmail written in PHP and JavaScript

KMail is the email component of Kontact, the integrated personal information manager from KDE. It supports the standard mail protocols IMAP, POP3 and SMTP. It supports authentication via NTLM (Microsoft Windows) and GSSAPI (Kerberos). It has  native support for inline OpenPGP, PGP/MIME, and S/MIME.    

KMail - KDE Email Application

Fetchmail is a full-featured, robust, well-documented remote-mail retrieval and forwarding utility intended to be used over on-demand TCP/IP links (such as SLIP or PPP connections). It supports every remote-mail protocol now in use on the Internet: POP2, POP3, RPOP, APOP, KPOP, all flavors of IMAP, ETRN, and ODMR. It can even support IPv6 and IPSEC. 
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Fetchmail retrieves mail from remote mail servers and forwards it via SMTP, so it can then be read by normal mail user agents such as mutt, elm(1) or BSD Mail. It allows all your system MTA's filtering, forwarding, and aliasing facilities to work just as they would on normal mail. Fetchmail can be used as a POP/IMAP-to-SMTP gateway for an entire DNS domain, collecting mail from a single drop box on an ISP and SMTP-forwarding it based on header addresses. (We don't really recommend this, though, as it may lose important envelope-header information. ETRN or a UUCP connection is better.)

Fetchmail is a full-featured, robust, well-documented remote-mail retrieval and forwarding utility intended to be used over on-demand TCP/IP links (such as SLIP or PPP connections). It supports every remote-mail protocol now in use on the Internet: POP2, POP3, RPOP, APOP, KPOP, all flavors of IMAP, ETRN, and ODMR. It can even support IPv6 and IPSEC.

fetchmail - TLS-enabled mail retrieval and forwarding agent

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Claws Mail - Email Client and News Reader Based on GTK+

Thunderbird - Email Client

SharpWebMail - ASP.NET Webmail Application

Sylpheed - Lightweight and user-friendly e-mail client

Cypht - Lightweight Open Source webmail written in PHP and JavaScript

KMail - KDE Email Application

fetchmail - TLS-enabled mail retrieval and forwarding agent

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Claws Mail - Email Client and News Reader Based on GTK+

Thunderbird - Email Client

SharpWebMail - ASP.NET Webmail Application

Sylpheed - Lightweight and user-friendly e-mail client

Cypht - Lightweight Open Source webmail written in PHP and JavaScript

KMail - KDE Email Application

fetchmail - TLS-enabled mail retrieval and forwarding agent

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