Claws Mail is a GTK+ based, lightweight, and fast e-mail client and newsreader. Supports POP3, APOP, IMAP, SMTP, SMTP AUTH, NNTP, LDAP, multiple accounts, spell-checking, addressbook, SSL, GPG, filtering, i18n, & more. It is further extended by plugins. Lots of extra functionality, like an RSS aggregator, calendar, or laptop LED handling, are provided by extra plugins. 

Claws Mail - Email Client and News Reader Based on GTK+

Mailspring is built on the modern web with Electron, React, and Flux. It is designed to be extensible, so it's easy to create new experiences and workflows around email. 
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Mailspring comes packed with powerful features like Unified Inbox, Snooze, Send Later, Mail Rules, Templates and more. Mailspring Pro, which you can unlock with a monthly subscription, adds even more features for people who send a ton of email: link tracking, read receipts, mailbox analytics, contact and company profiles. All of these features run in the client - Mailspring does not send your email credentials to the cloud. 
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You can have unified inbox as it supports every major mail provider—Gmail, iCloud, Office 365, Outlook.com, Yahoo!, and IMAP/SMTP—so you have a single, streamlined command center for all your messages. 

Mailspring is built on the modern web with Electron, React, and Flux. It is designed to be extensible, so it's easy to create new experiences and workflows around email. 

Mailspring - A beautiful, fast Webmail

Thunderbird is most popular simple e-mail, newsgroup and news feed client. It is comparable to Microsoft outlook. It supports features such as Firefox's tabbed browsing, Email search, Message archive, Spam filtering, Message grouping, SSL, TLS, POP3 and IMAP support and lot more.

Thunderbird - Email Client

Hastymail is a fast, secure, rfc-compliant, cross-platform IMAP/SMTP client application written in PHP providing a clean web interface for sending and reading E-mail. It is compatible with PDAs, phones, text browsers, and all mainstream browsers. The ability to use a database for storing user settings, contacts, and plugin data, with support for both Postgresql and Mysql. 

Hastymail - IMAP/SMTP client in PHP

Sylpheed is a simple, lightweight but featureful, and easy-to-use e-mail client. It provides intuitive user-interface, Powerful filtering and search, Junk mail control, Security features (GnuPG, SSL/TLSv1). Sylpheed supports not only the major protocols such as POP3, IMAP4rev1 and SMTP, but also NNTP (NetNews). IPv6, which is the next-generation Internet protocol, is also supported by default.

Sylpheed - Lightweight and user-friendly e-mail client

SquirrelMail is a PHP-based Web email client. It includes built-in pure PHP support for IMAP and SMTP, and renders all pages in pure HTML 4.0 for maximum compatibility across browsers. It has strong MIME support and a flexible plugin system. 

SquirrelMail - Webmail

Geary is an email application built around conversations, for the GNOME 3 desktop. It allows you to read, find and send email with a straightforward, modern interface. 

Geary - Email Application to Send and Receive mails

KMail is the email component of Kontact, the integrated personal information manager from KDE. It supports the standard mail protocols IMAP, POP3 and SMTP. It supports authentication via NTLM (Microsoft Windows) and GSSAPI (Kerberos). It has  native support for inline OpenPGP, PGP/MIME, and S/MIME.    

KMail - KDE Email Application

Isotope Mail client is a microservice based webmail client built with ReactJS and Spring. One of the main reasons to develop Isotope Mail is to learn and showcase new technologies, frameworks and libraries and how they can be used in a real life product. There is a stronger focus on achieving top quality code rather than delivering a large number of features.



Isotope Mail Client - Microservice based webmail client built with ReactJS and Spring

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