Sequelize is a promise-based Node.js ORM for Postgres, MySQL, SQLite and Microsoft SQL Server. It features solid transaction support, relations, read replication and more.

Sequelize - An easy-to-use multi SQL dialect ORM for Node.js

MongoDB object modeling designed to work in an asynchronous environment. It provides a straight-forward, schema-based solution to modeling your application data and includes built-in type casting, validation, query building, business logic hooks and more, out of the box.

Mongoose - Elegant MongoDB object modeling for Node.js

Objection.js is an ORM for Node.js that aims to stay out of your way and make it as easy as possible to use the full power of SQL and the underlying database engine while keeping magic to a minimum.Objection.js is built on an SQL query builder called knex. All databases supported by knex are supported by objection.js. SQLite3, Postgres and MySQL are thoroughly tested.

Objection.js - An SQL-friendly ORM for Node.js

Bookshelf is a JavaScript ORM for Node.js, built on the Knex SQL query builder. Featuring both promise based and traditional callback interfaces, providing transaction support, eager/nested-eager relation loading, polymorphic associations, and support for one-to-one, one-to-many, and many-to-many relations. It is designed to work well with PostgreSQL, MySQL, and SQLite3.
 
Bookshelf aims to provide a simple library for common tasks when querying databases in JavaScript, and forming relations between these objects, taking a lot of ideas from the the Data Mapper Pattern.

 Bookshelf is a JavaScript ORM for Node.js, built on the Knex SQL query builder. Featuring both promise based and traditional callback interfaces, providing transaction support, eager/nested-eager relation loading, polymorphic associations, and support for one-to-one, one-to-many, and many-to-many relations. It is designed to work well with PostgreSQL, MySQL, and SQLite3.

Bookshelf - A simple Node.js ORM for PostgreSQL, MySQL and SQLite3 built on top of Knex.js

Knex.js is a "batteries included" SQL query builder for Postgres, MSSQL, MySQL, MariaDB, SQLite3, Oracle, and Amazon Redshift designed to be flexible, portable, and fun to use. It features both traditional node style callbacks as well as a promise interface for cleaner async flow control, a stream interface, full featured query and schema builders, transaction support (with savepoints), connection pooling and standardized responses between different query clients and dialects.

knex.js - A SQL query builder that is flexible, portable, and fun to use

Waterline is a new kind of storage and retrieval engine. 
It provides a uniform API for accessing stuff from different kinds of databases, protocols, and 3rd party APIs. That means you write the same code to get and store things like users, whether they live in Redis, mySQL, LDAP, MongoDB, or Postgres.
 
Waterline strives to inherit the best parts of ORMs like ActiveRecord, Hibernate, and Mongoose, but with a fresh perspective and emphasis on modularity, testability, and consistency across adapters.

Waterline is a new kind of storage and retrieval engine. 
It provides a uniform API for accessing stuff from different kinds of databases, protocols, and 3rd party APIs. That means you write the same code to get and store things like users, whether they live in Redis, mySQL, LDAP, MongoDB, or Postgres.


Waterline - An adapter based ORM for use with Node.js and the Sails.js Framework

JugglingDB is cross-db ORM for nodejs, providing common interface to access most popular database formats. Currently supported are: mysql, sqlite3, postgres, mongodb, redis and js-memory-storage (yep, self-written engine for test-usage only). You can add your favorite database adapter, checkout one of the existing adapters to learn how. 
Jugglingdb also works on client-side (using WebService and Memory adapters), which allows to write rich client-side apps talking to server using JSON API.

JugglingDB is cross-db ORM for nodejs, providing common interface to access most popular database formats. Currently supported are: mysql, sqlite3, postgres, mongodb, redis and js-memory-storage (yep, self-written engine for test-usage only). You can add your favorite database adapter, checkout one of the existing adapters to learn how.

JugglingDB - Multi-database ORM in NodeJS

rdb is a ORM for Nodejs. It has support for postgres, mySql and sqlite. It is Simple, flexible mapper and Based on promises. It supports transaction with commit and rollback.

rdb - Javascript ORM

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